Research Overview

My research focuses on applying health economics, statistical modelling, and real-world data to understand how diseases and treatments affect healthcare utilization, clinical outcomes, employment, productivity, and economic outcomes.

My work spans:

  • Health economics and economic evaluation
  • Real-world evidence (RWE)
  • Health technology assessment (HTA)
  • Healthcare resource utilization (HCRU)
  • Treatment patterns and persistence
  • Rare disease research
  • Administrative health databases
  • Longitudinal and panel data
  • Survival and time-to-event analysis
  • Difference-in-differences
  • Mixed and hierarchical models
  • Cost and economic models
  • Health outcomes research
  • Labor-market and productivity outcomes

Publications & Research

Publications

  1. Traumatic cervical spinal cord injury and income and employment status RH Jaffe, PC Coyte, BCF Chan, RL Hancock-Howard, AK Malhotra, et al. JAMA Network Open 7(6), e2418468, 2024 — Cited by 23 View

  2. Earlier tracheostomy reduces complications in complete cervical spinal cord injury in real-world practice: analysis of a multicenter cohort of 2001 patients M Balas, BNR Jaja, EM Harrington, AS Jack, J Hofereiter, AK Malhotra, et al. Neurosurgery 93(6), 1305–1312, 2023 — Cited by 18 View

  3. Association between trauma center type and mortality for injured children with severe traumatic brain injury AK Malhotra, B Patel, CJ Hoeft, H Shakil, CW Smith, R Jaffe, AV Kulkarni, et al. Journal of Trauma and Acute Care Surgery 96(5), 777–784, 2024 — Cited by 17 View

  4. Factors influencing withdrawal of life-supporting treatment in cervical spinal cord injury: a large multicenter observational cohort study H Shakil, AK Malhotra, RH Jaffe, CW Smith, EM Harrington, AP Wang, et al. Critical Care 27(1), 448, 2023 — Cited by 17 View

  5. Assessment of the incremental prognostic value from the modified frailty index-5 in complete traumatic cervical spinal cord injury H Shakil, BNR Jaja, PF Zhang, RH Jaffe, AK Malhotra, EM Harrington, et al. Scientific Reports 13(1), 7578, 2023 — Cited by 14 View

  6. Multicenter retrospective cohort study of the association between surgery for odontoid fractures in the elderly and in-hospital outcomes Z Merali, PF Zhang, RH Jaffe, BNR Jaja, EM Harrington, AK Malhotra, et al. Scientific Reports 13(1), 6276, 2023 — Cited by 6 View

  7. Impact of major postoperative complications on employment and earnings after elective hip or knee replacement surgery: a population-based matched cohort study C Diep, R Jaffe, C Witiw, JF Daza, DN Wijeysundera, B Ravi, KS Ladha Canadian Journal of Anesthesia/Journal canadien d’anesthésie 72(5), 738–747, 2025 — Cited by 2 View

  8. Scheduling, income, and school closures: unlocking the key drivers of home care personal support unplanned absences through time-to-event regression analysis KAP Zagrodney, R Jaffe, SM McKay, K Mangal, TA Van Belle, KA Nichol, et al. Journal of Applied Gerontology 44(11), 1854–1866, 2025 — Cited by 1 View

  9. Comparison of Age and Modified Frailty Index-5 as Predictors of In-Hospital Mortality in Complete Traumatic Cervical Spinal Cord Injury H Shakil, BNR Jaja, PF Zhang, RH Jaffe, AK Malhotra, EM Harrington, et al. 2022 — Cited by 1 View

  10. The Cost of Homecare Personal Support Worker Turnover KAP Zagrodney, SM McKay, E Sequera, K Myers, D Uzelac, R Jaffe, et al. Healthcare Management Forum, 2026 View

  11. WCN26-2528 Early Insights Into Characteristics and Treatment Patterns of US Patients With Complement 3 Glomerulopathy Who Were Prescribed Iptacopan: The APPRISE-C3G Data Platform M Narayanan, B Ndife, R Khairnar, H Trenz, A Bose, N Stephens, et al. Kidney International Reports 11(4), 2026 View

  12. The impact of perioperative complications on employment and earnings after elective hip or knee replacement surgery: a population-based cohort study C Diep, R Jaffe, C Witiw, DN Wijeysundera, KS Ladha CAS 2024 Annual Meeting Abstract Book 71, 174, 2024 View

  13. Impact of Traumatic Spinal Cord Injury on Income and Employment Status in a National Canadian Cohort R Jaffe University of Toronto (Canada), 2023 View

  14. Association between Surgery for Odontoid Fractures in the Elderly and in-hospital Outcomes: Analysis from the American College of Surgeons Trauma Quality Improvement Program Z Merali, PF Zhang, RH Jaffe, BNR Jaja, EM Harrington, AK Malhotra, et al. 2022 View